Haemolytic anaemias due to hexose monophosphate shunt or glutathione metabolism anomalies

This is a form of anaemia due to haemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular haemolysis) or elsewhere in the human body (extravascular). This diagnosis is due to a process that generates NADPH and pentoses (5-carbon sugars) and glutathione metabolism anomalies.